Freeze the beef for 30-45 minutes to make it easier to slice.
Using a sharp knife, slice the beef against the grain into ⅛ to ¼-inch thick strips.
In a mixing bowl, whisk together soy sauce, Worcestershire sauce, vinegar, black pepper, onion powder, garlic powder, red pepper flakes, and liquid smoke.
Add the sliced beef, making sure each piece is well coated.
Cover and refrigerate for at least 6 hours (or overnight for maximum flavor).
Preheat the oven to 170°F (75°C).
Line a baking sheet with foil and place a wire rack on top.
Arrange the marinated beef strips in a single layer on the rack.
Bake for 4-6 hours, flipping halfway through, until the jerky is dry but still slightly flexible.
Place the marinated beef strips on the dehydrator trays, leaving space between each piece.
Set the dehydrator to 160°F (70°C) and dry for 4-6 hours until the jerky is firm but still slightly chewy.
Let the jerky cool completely before storing.
Store in an airtight container at room temperature for 1-2 weeks, or in the fridge for up to 1 month.